A hepatoprotective agent; reduces viral DNA and the secretion of HBsAg and HBeAg by 59 and 35%

Bicyclol – 1 mg

Brand:
Cayman
CAS:
118159-48-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Bicyclol is a hepatoprotective agent.{37151,37152,37153,37154} It has antiviral activity against hepatitis B (HBV), reducing viral DNA and the secretion of the HBV antigens HBsAg and HBeAg by 59 and 35%, respectively, in infected 2.2.15 HepG2 cells.{37151} In vivo, bicyclol reduces duck HBV (DHBV) DNA in DHBV-infected ducks at doses ≥0.4 g/kg. It also reduces the expression of TNF-α and the accumulation of lymphocytes in the liver in a mouse model of liver injury induced by concanavalin A (Item No. 14951).{37152} Oral administration of bicyclol prior to injection of diethylnitrosamine (DEN) and phenobarbital (PB; Item Nos. 9001494 | 20987) prevents formation of DEN/PB-induced hepatocellular carcinomas.{37153} It also reduces liver fibrosis in a rat model of bile duct ligation-induced hepatic fibrosis.{37154}  

 

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Description

A hepatoprotective agent; reduces viral DNA and the secretion of HBsAg and HBeAg by 59 and 35%, respectively, in infected 2.2.15 HepG2 cells; reduced DHBV DNA in DHBV-infected ducks at doses ≥0.4 g/kg; reduces the expression of TNF-α and the accumulation of lymphocytes in the liver in a mouse model of concanavalin A-induced liver injury; prevents formation of DEN/PB-induced hepatocellular carcinomas; reduces liver fibrosis in a rat model of bile duct ligation-induced hepatic fibrosis

Formal name: 5′-(hydroxymethyl)-7,7′-dimethoxy-[4,4′-bi-1,3-benzodioxole]-5-carboxylic acid, methyl ester

Synonyms: 

Molecular weight: 390.3

CAS: 118159-48-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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