A neuroprotective agent; potentiates NGF-induced neurite outgrowth in NS-1 cells (EC50 = ~1 μM); inhibits glutamate-induced excitotoxicity in HT-22 cells in a concentration-dependent manner; inhibits glutamate-induced decreases in GSH levels and increases in Bax levels

B355252 – 50 mg

Brand:
Cayman
CAS:
1261576-81-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

B355252 is a neuroprotective agent.{52030,52031,52032} It potentiates NGF-induced neurite outgrowth in NS-1 cells (EC50 = ~1 μM).{52030} B355252 inhibits glutamate-induced excitotoxicity in HT-22 cells in a concentration-dependent manner and inhibits glutamate-induced decreases in GSH levels and increases in Bax levels, intracellular accumulation of calcium, and production of reactive oxygen species (ROS) in HT-22 cells when used at a concentration of 8 μM.{52031} It also inhibits decreases in cell viability, increases in ROS production, and mitochondrial membrane depolarization induced by 6-hydroxydopamine (6-OHDA; Item No. 25330) in HT-22 cells, an in vitro model of Parkinson’s disease.{52032}  

 

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Description

A neuroprotective agent; potentiates NGF-induced neurite outgrowth in NS-1 cells (EC50 = ~1 μM); inhibits glutamate-induced excitotoxicity in HT-22 cells in a concentration-dependent manner; inhibits glutamate-induced decreases in GSH levels and increases in Bax levels, intracellular accumulation of calcium, and ROS production in HT-22 cells at 8 μM; inhibits decreases in cell viability, increases in ROS production, and mitochondrial membrane depolarization induced by 6-OHDA in HT-22 cells, an in vitro model of Parkinson’s disease

Formal name: 4-chloro-N-(1-naphthalenylmethyl)-5-[3-(1-piperazinyl)phenoxy]-2-thiophenesulfonamide

Synonyms: 

Molecular weight: 514.1

CAS: 1261576-81-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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