A positive allosteric modulator of δ-opioid receptors (EC50 = 0.05 μM in a β-arrestin recruitment assay in the presence

BMS 986188 – 10 mg

Brand:
Cayman
CAS:
1776115-10-6
Storage:
-20
UN-No:
Non-Hazardous - /

BMS 986188 is a positive allosteric modulator of δ-opioid receptors, with an EC50 value of 0.05 μM in a β-arrestin recruitment assay in the presence, but not absence, of the opioid receptor agonist leu-enkephalin (Item No. 23283).{38565} It is selective for δ- over μ-opioid receptors (EC50 = >10 μM) in the presence of leu-enkephalin and the μ-opioid receptor agonist endomorphin 1 (Item No. 23280), respectively.  

 

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Description

A positive allosteric modulator of δ-opioid receptors (EC50 = 0.05 μM in a β-arrestin recruitment assay in the presence, but not absence, of leu-enkephalin); selective for δ- over μ-opioid receptors (EC50 = >10 μM) in the presence of leu-enkephalin and endomorphin 1, respectively

Formal name: 9-[4-[(2-bromophenyl)methoxy]phenyl]-3,4,5,6,7,9-hexahydro-3,3,6,6-tetramethyl-1H-xanthene-1,8(2H)-dione

Synonyms: 

Molecular weight: 535.5

CAS: 1776115-10-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Neuroscience

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