An inhibitor of mutant IDH1; reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36

ML-309 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1355327-02-4
Storage:
-20
UN-No:
Non-Hazardous - /

ML-309 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1).{42529} It reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36,500 nM, respectively). ML-309 reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells (EC50 = 55 nM).  

 

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Description

An inhibitor of mutant IDH1; reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36,500 nM, respectively); reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells (EC50 = 55 nM)

Formal name: N-[2-(cyclopentylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-1H-benzimidazole-1-acetamide, monohydrochloride

Synonyms: 

Molecular weight: 521

CAS: 1355327-02-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Metabolism

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