Description
A selective inhibitor of CHOKα (IC50s = 1 and >50 μM for CHOKα and β, respectively); induces apoptosis via CHOP signaling and ER stress in MDA-MB-231, MCF-7, SW620, and H460 cancer cells; inhibits the growth of HT-29 colon cancer cells in vitro (IC50 = 1.15 μM) and in vivo in a mouse xenograft model (ED50 = 7.5 mg/kg) ,
Formal name: 1,1′-[[[1,1′-biphenyl]-4,4′-diyl]bis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium, dibromide
Synonyms:
Molecular weight: 877.5
CAS: 850807-63-5
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling