A potent 5-HT1Dβ receptor agonist (EC50 = 68 nM for inhibition of adenylate cyclase activity); selective for 5-HT1Dβ over 5-HT1A for its adenylate cyclase activity (EC50 = >1 μM for 5-HT1A; binds to 5-HT1Dβ

Nonyloxytryptamine (oxalate) – 1 mg

Brand:
Cayman
CAS:
157798-13-5
Storage:
-20
UN-No:
Non-Hazardous - /

Nonyloxytryptamine is a potent agonist of the serotonin (5-HT) receptor 5-HT1Dβ with an EC50 value of 68 nM for adenylate cyclase activity in CHOKM6 cells transfected with the human 5-HT1Dβ receptor.{38242} It is selective for 5-HT1Dβ over 5-HT1A for its adenylate cyclase activity, with an EC50 greater than 1 μM for 5-HT1A. It binds to 5-HT1Dβ, 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptors in vitro (Kis = 1.2-315 nM). Nonyloxytryptamine also inhibits reovirus-mediated cell death in a dose-dependent manner but has no effect on reovirus attachment or internalization.{38243}  

 

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Description

A potent 5-HT1Dβ receptor agonist (EC50 = 68 nM for inhibition of adenylate cyclase activity); selective for 5-HT1Dβ over 5-HT1A for its adenylate cyclase activity (EC50 = >1 μM for 5-HT1A; binds to 5-HT1Dβ, 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptors in vitro (Kis = 1.2-315 nM); inhibits reovirus-mediated cell death in a dose-dependent manner but has no effect on reovirus attachment or internalization,

Formal name: 5-(nonyloxy)-1H-indole-3-ethanamine, monoethanedioate

Synonyms: 

Molecular weight: 392.5

CAS: 157798-13-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases||Research Area|Neuroscience

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