A nonpeptide antagonist of vasopressin V2 receptors (Ki = 2.3 nM)

Lixivaptan – 5 mg

Brand:
Cayman
CAS:
168079-32-1
Storage:
-20
UN-No:
Non-Hazardous - /

Lixivaptan is a nonpeptide antagonist of vasopressin V2 receptors (Ki = 2.3 nM).{34309} It is 100-fold selective for V2 over V1a.{27294} Formulations containing lixivaptan decrease urinary excretion of aquaporin-2 in patients with chronic heart failure and increase serum sodium levels in patients with hyponatremia due to congestive heart failure.{34307,34308}  

 

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Description

A nonpeptide antagonist of vasopressin V2 receptors (Ki = 2.3 nM)

Formal name: N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methyl-benzamide

Synonyms:  VPA-985|WAY-VPA-985

Molecular weight: 473.9

CAS: 168079-32-1

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Endocrinology & Metabolism|Hormones & Receptors

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