A potent inhibitor at FLT3 and AXL tyrosine kinase inhibitors (IC50 = 0.29 nM and

Gilteritinib – 5 mg

Brand:
Cayman
CAS:
1254053-43-4
Storage:
-20
UN-No:
Non-Hazardous - /

Gilteritinib is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively).{33768} In preclinical studies, gilteritinib showed strong antileukemic and antitumor effects.{33769,33767} Gilteritinib is currently in several Phase 3 clinical trials for acute myeloid leukemia.  

 

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Description

A potent inhibitor at FLT3 and AXL tyrosine kinase inhibitors (IC50 = 0.29 nM and <1 nM, respectively)

Formal name: 6-ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide

Synonyms:  ASP2215

Molecular weight: 552.7

CAS: 1254053-43-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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