A peptide agonist of FPRs; induces cellular activation in phagocytes; induces contractions in isolated guinea pig jejunum (EC50 = 11 nM)

N-Formyl-Met-Leu-Phe – 25 mg

Brand:
Cayman
CAS:
59880-97-6
Storage:
-20
UN-No:
Non-Hazardous - /

N-Formyl-Met-Leu-Phe (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors (FPRs; Ki = 0.8 pM), which are mainly localized on polymorphonuclear and mononuclear phagocytes.{34517} Activation of FPRs by fMLF leads to cellular activation, which is characterized by cellular polarization, chemotaxis, and release of proteolytic enzymes.{34518} fMLF induces contractions in isolated guinea pig jejunum (EC50 = 11 nM), proximal colon (EC50 = 3.5 nM), and distal colon (EC50 = 2.2 nM).{34516} In vitro, fMLF induces neurotransmitter release from enteric motor neurons.  

 

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Description

A peptide agonist of FPRs; induces cellular activation in phagocytes; induces contractions in isolated guinea pig jejunum (EC50 = 11 nM), proximal colon (EC50 = 3.5 nM), and distal colon (EC50 = 2.2 nM)

Formal name: N-formyl-L-methionyl-L-leucyl-L-phenylalanine

Synonyms:  Chemotactic Peptide|fMLP|NSC 350593

Molecular weight: 437.6

CAS: 59880-97-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Innate Immunity

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