A Chk1 inhibitor (Ki = 0.9 nM); IC50 values of 2/M checkpoint in HeLa cells; induces apoptosis in gastric cancer cell lines

LY2606368 – 25 mg

Brand:
Cayman
CAS:
1234015-52-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

LY2606368 is a checkpoint kinase 1 (Chk1) inhibitor with a Ki value of 0.9 nM against the purified target and IC50 values of In vitro, LY2606368 inhibits the doxorubicin-activated G2/M checkpoint in p53-deficient HeLa cells with an EC50 value of 9 nM.{34611} LY2606368, at 25 nM, also significantly induces apoptosis and inhibits colony formation in AGS and MKN1 gastric cancer cells.{34613}  

 

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Description

A Chk1 inhibitor (Ki = 0.9 nM); IC50 values of 2/M checkpoint in HeLa cells; induces apoptosis in gastric cancer cell lines

Formal name: 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile

Synonyms:  Prexasertib

Molecular weight: 365.4

CAS: 1234015-52-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Checkpoint Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling||Research Area|Cancer|DNA Damage and Repair

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