A selective inhibitor of Bcl-xL (IC50 = 1.1 nM); induces apoptosis specifically in Mcl-1 deficient cells and does not affect Bcl-2 overexpressing cells

WEHI-539 – 10 mg

Brand:
Cayman
CAS:
1431866-33-9
Storage:
-20
UN-No:
De Minimis - 3077 / 9

WEHI-539 is an inhibitor of Bcl-xL (IC50 = 1.1 nM) that demonstrates more than 400-fold selectivity for Bcl-xL over Bcl-2, Mcl-1, Bcl-W, or A1.{33606} It has been shown to induce apoptosis specifically in Mcl-1 deficient cells and does not affect Bcl-2 overexpressing cells.{33606} WEHI-539 can be used as a tool for distinguishing the roles of Bcl-xL in both normal and cancer cells from those of the related prosurvival proteins such as Bcl-2 and Mcl-1.{33606}  

 

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Description

A selective inhibitor of Bcl-xL (IC50 = 1.1 nM); induces apoptosis specifically in Mcl-1 deficient cells and does not affect Bcl-2 overexpressing cells

Formal name: 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid

Synonyms: 

Molecular weight: 583.7

CAS: 1431866-33-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis

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