A prodrug form of LBQ657; increases plasma levels of ANF in concious rats and anesthetized dogs at 10 and 30 mg/kg

AHU377 (calcium salt) – 10 mg

Brand:
Cayman
CAS:
1369773-39-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

AHU377 is a methyl ester prodrug from of the neprilysin inhibitor LBQ657 (Item No. 19829).{42277} It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used for the treatment of mild to moderate hypertension and chronic heart failure.  

 

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Description

A prodrug form of LBQ657; increases plasma levels of ANF in concious rats and anesthetized dogs at 10 and 30 mg/kg, respectively; increases ANF-induced urinary sodium excretion in anesthetized rats at 30 mg/kg,

Formal name: (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1’-biphenyl]-4-pentanoic acid, 4-ethyl ester, hemicalcium salt

Synonyms:  Sacubitril

Molecular weight: 430.5

CAS: 1369773-39-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension

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