A potent

Odanacatib – 25 mg

Brand:
Cayman
CAS:
603139-19-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (IC50s = 0.2 and 1 nM for human and rabbit enzymes, respectively), a protease involved in osteoclastic bone resorption.{33648} It demonstrates high selectivity for cathepsin K over cathepsins B, L, and S. Formulations containing odanacatib reduce bone resorption, with lesser reductions in bone formation, resulting in increased bone mineral density.{33647,33649}  

 

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Description

A potent, selective, and neutral inhibitor of cathepsin K (IC50s = 0.2 and 1 nM for human and rabbit enzymes, respectively)

Formal name: (2S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]ethyl]amino]-pentanamide

Synonyms:  MK-0822

Molecular weight: 525.6

CAS: 603139-19-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling

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