An mGluR antagonist; the active component of (±)-MCPG; inhibits ACPD-induced intracellular calcium increases in CHO cells expressing mGluR1α (IC50 = 120 µM); has agonist activity at mGluR2

(S)-MCPG – 5 mg

Brand:
Cayman
CAS:
150145-89-4
Storage:
-20
UN-No:
Non-Hazardous - /

(S)-MCPG is an antagonist of metabotropic glutamate receptors (mGluRs) and the active component of (±)-MCPG, which is selective for Group I and Group II mGluRs.{36912,21635} (S)-MCPG inhibits motoneuron depolarization induced by 1-amino-1,3-dicarboxycyclopentane (ACPD) in neonatal rat spinal cord in vitro and ACPD-induced intracellular calcium increases in CHO cells expressing mGluR1α (IC50 = 120 µM).{36913} (S)-MCPG also has agonist activity at mGluR2.{36914,36915} It induces long-term depression in the rat hippocampal dentate gyrus, an effect that can be blocked by the mGluR2 antagonist MCCG, and blocks long-term potentiation in the CA1 region.  

 

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Description

An mGluR antagonist; the active component of (±)-MCPG; inhibits ACPD-induced intracellular calcium increases in CHO cells expressing mGluR1α (IC50 = 120 µM); has agonist activity at mGluR2, inducing long-term depression in rat hippocampal dentate gyrus, an effect that can be blocked by an mGluR2 antagonist; blocks long-term potentiation in the CA1 region

Formal name: (αS)-α-amino-4-carboxy-α-methyl-benzeneacetic acid

Synonyms:  (+)-MCPG|(+)-α-methyl-4-Carboxyphenylglycine|(S)-α-methyl-4-Carboxyphenylglycine

Molecular weight: 209.2

CAS: 150145-89-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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