An NSAID that inhibits cytokine-induced COX-2 expression and NFκB activation; also inhibits various ion channels

Flufenamic Acid – 100 g

Brand:
Cayman
CAS:
530-78-9
Storage:
-20
UN-No:
Limited Quantity - 2811 / 6.1

Flufenamic acid is an anthranilic acid-derived nonsteroidal anti-inflammatory drug (NSAID) thought to exert its actions by a prostanoid-independent mechanism. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNLs with IC50 values of 29 and 14 µM, respectively.{1819} It is also reported to inhibit cytokine-induced COX-2 expression and NFκB activation.{8510} Additionally, flufenamic acid has been described as an inhibitor of various ion channels, including TRP channels (TRPC3, TRPC5, TRPC6, TRPC7, TRPM2, TRPM4, and TRPM5).{24047}  

 

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Description

An NSAID that inhibits cytokine-induced COX-2 expression and NFκB activation; also inhibits various ion channels, including TRP channels (TRPC3, TRPC5, TRPC6, TRPC7, TRPM2, TRPM4, and TRPM5)

Formal name: 2-[[3-(trifluoromethyl)phenyl]amino]-benzoic acid

Synonyms:  CI-440|Fluphenamic Acid|NSC 219007|NSC 82699

Molecular weight: 281.2

CAS: 530-78-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Immunology & Inflammation

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