A thiocarbamate antifungal agent; active against dermatophyte clinical isolates (MIC50 = 6-100 ng/ml) and 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 µg/ml); reduces aflatoxin production in A. parasiticus in a concentration-dependent manner; inhibits squalene epoxidase (IC50 = 12.5 µg/ml in a cell-free assay)

Tolnaftate – 1 g

Brand:
Cayman
CAS:
2398-96-1
Storage:
-20
UN-No:
Non-Hazardous - /

Tolnaftate is a thiocarbamate antifungal agent.{53200} It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 µg/ml).{17905},{25586} Tolnaftate also reduces aflatoxin production in A. parasiticus in a concentration-dependent manner.{53199} It inhibits squalene epoxidase with an IC50 value of 12.5 µg/ml in a cell-free assay.{53200}  

 

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Description

A thiocarbamate antifungal agent; active against dermatophyte clinical isolates (MIC50 = 6-100 ng/ml) and 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 µg/ml); reduces aflatoxin production in A. parasiticus in a concentration-dependent manner; inhibits squalene epoxidase (IC50 = 12.5 µg/ml in a cell-free assay)

Formal name: N-methyl-N-(3-methylphenyl)-carbamothioic acid, O-2-naphthalenyl ester

Synonyms:  NSC 233648|SCH 10144

Molecular weight: 307.4

CAS: 2398-96-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Ringworm

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