A β-carboline alkaloid with diverse activities; inhibits GSK3β and CDK5 (IC50s = 10.2 and 1.5 μM

Manzamine A – 500 µg

Brand:
Cayman
CAS:
104196-68-1
Storage:
-20
UN-No:
Non-Hazardous - /

Manzamine A is a β-carboline alkaloid with diverse activities that has been found in marine sponges, including X. ashmorica.{42149} It is an inhibitor of glycogen synthase kinase 3β (GSK3β) and cyclin-dependent kinase 5 (CDK5; IC50s = 10.2 and 1.5 μM, respectively).{42150} It inhibits the growth of L5178y mouse lymphoma cells with an ED50 value of 1.8 μg/mL.{42149} In an agar diffusion assay, manzamine A inhibits the growth of B. subtilis and S. aureus, but not E. coli bacteria. It reduces the reverse transcriptase (RT) activity in supernatant from HIV-1-infected peripheral blood mononuclear cells (PBMCs; EC50 = 4.2 μM).{42151} In vivo, manzamine A (100 μmol/kg, i.p.) has antimalarial activity and reduces the amount of P. berghei in infected mice by over 90% relative to the control.{42152} Manzamine A (132 ppm) inhibits the growth of S. littoralis larva by 80% when added to the larval diet.{42149}  

 

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Description

A β-carboline alkaloid with diverse activities; inhibits GSK3β and CDK5 (IC50s = 10.2 and 1.5 μM, respectively); inhibits the growth of L5178y mouse lymphoma cells (ED50 = 1.8 μg/mL); inhibits the growth of B. subtilis and S. aureus; reduces RT activity in supernatant from human PBMCs infected with HIV-1 (EC50 = 4.2 μM); reduces the amount of P. berghei in infected mice by over 90% relative to the control at 100 μmol/kg, i.p.; inhibits the growth of S. littoralis larva by 80% when added to the diet at 132 ppm,

Formal name: (1R,4S,9Z,13S,13aR,20aR,21aR)-2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-1,13-etheno-4,21a-methano-1H-azocino[1′,2′:1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol

Synonyms:  Keramamine A

Molecular weight: 548.8

CAS: 104196-68-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Neuroscience

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