A selective inhibitor of PARP1 (IC50 = 44.67 nM for human recombinant PARP); selective for PARP1 over PARP2 (IC50 = 4

BYK204165 – 1 mg

Brand:
Cayman
CAS:
1104546-89-5
Storage:
-20
UN-No:
Non-Hazardous - /

BYK204165 is a selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay).{22587} It is selective for PARP1 over PARP2 (IC50 = 4,168 nM for murine PARP2 in an enzyme assay). BYK204165 inhibits hydrogen peroxide-activated PARP in A549 human lung epithelial, C4I human cervical, and H9c2 rat cardiac myoblast cells with IC50 values of 229.09, 1,778.28, and 123.03 nM, respectively.  

 

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Description

A selective inhibitor of PARP1 (IC50 = 44.67 nM for human recombinant PARP); selective for PARP1 over PARP2 (IC50 = 4,168 nM); inhibits hydrogen peroxide-activated PARP in A549 human lung epithelial, C4I human cervical, and H9c2 rat cardiac myoblast cells (IC50s = 229.09, 1,778.28, and 123.03 nM, respectively)

Formal name: 4-[(1-methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione

Synonyms:  PARP Inhibitor XIV

Molecular weight: 252.3

CAS: 1104546-89-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|DNA Damage and Repair|PARP

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