A gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes); a dose of 1 mg/kg slows intestinal transit and induces constipation in mice; induces serum hyperammonemia; decreases clonic

Clidinium (bromide) – 500 mg

Brand:
Cayman
CAS:
3485-62-9
Storage:
-20
UN-No:
Non-Hazardous - /

Clidinium is a gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes).{39282} Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice.{39283} This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.  

 

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Description

A gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes); a dose of 1 mg/kg slows intestinal transit and induces constipation in mice; induces serum hyperammonemia; decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model,

Formal name: 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane, monobromide

Synonyms:  Ro 2-3773

Molecular weight: 432.4

CAS: 3485-62-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Seizure Disorders

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