A fluoroquinolone antibiotic; active against S. aureus

Rufloxacin (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
106017-08-7
Storage:
-20
UN-No:
Non-Hazardous - /

Rufloxacin is a fluoroquinolone antibiotic.{48509} It is active against S. aureus, E. coli, P. aeruginosa, P. morganii, K. pneumoniae, and E. cloacae in vitro (MICs = 0.78, 0.78, 12.5, 1.56, M. luteus DNA gyrase with an IC50 value of 1.5 mM and inhibits DNA synthesis in S. aureus, E. coli, P. aeruginosa, K. pneumoniae, and E. cloacae (IC50s = 0.93, 1.03, 38.8, 0.55, and 0.66 μg/ml, respectively).{48511,48509} Rufloxacin (50 mg/kg, p.o.) reduces bacterial burden in the spleen and liver in a mouse model of systemic S. typhimurium infection.{48512}  

 

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Description

A fluoroquinolone antibiotic; active against S. aureus, E. coli, P. aeruginosa, P. morganii, K. pneumoniae, and E. cloacae in vitro (MICs = 0.78, 0.78, 12.5, 1.56, M. luteus DNA gyrase (IC50 = 1.5 mM); inhibits DNA synthesis in S. aureus, E. coli, P. aeruginosa, K. pneumoniae, and E. cloacae (IC50s = 0.93, 1.03, 38.8, 0.55, and 0.66 μg/ml, respectively); reduces bacterial burden in the spleen and liver in a mouse model of systemic S. typhimurium infection at 50 mg/kg, p.o.

Formal name: 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylic acid, monohydrochloride

Synonyms: 

Molecular weight: 399.9

CAS: 106017-08-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Quinolones & Fluoroquinolones||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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