A potent and selective agonist at mGluR5; EC50 of 750 µM for calcium mobilization in CHO mGluR5a-expressing cells but was inactive in mGluR1a-expressing cells; in transfected HEK293 cells

(R,S)-CHPG – 50 mg

Brand:
Cayman
CAS:
170846-74-9
Storage:
-20
UN-No:
Non-Hazardous - /

(R,S)-CHPG is a potent and selective agonist at metabotropic glutamate receptor 5 (mGluR5). In CHO cells, it had an EC50 of 750 µM for calcium mobilization in mGluR5a-expressing cells but was inactive in mGluR1a-expressing cells.{34104} In transfected HEK293 cells, (R,S)-CHPG bound mGluR1a and mGluR5a (Kis = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors.{23341} It reduced oxidative stress and inflammatory markers in cultured BV-2 microglial cells.{34106} In mouse models of traumatic brain injury, it reduced lesion volume, improved sensorimotor deficits in the beam walk test, and improved spatial memory in the Morris water maze.{34105}  

 

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Description

A potent and selective agonist at mGluR5; EC50 of 750 µM for calcium mobilization in CHO mGluR5a-expressing cells but was inactive in mGluR1a-expressing cells; in transfected HEK293 cells, (R,S)-CHPG bound mGluR1a and mGluR5a (Kis = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors

Formal name: α-amino-2-chloro-5-hydroxy-benzeneacetic acid

Synonyms:  Chlorohydroxyphenylglycine|CHPG

Molecular weight: 201.6

CAS: 170846-74-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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