A precursor of paclitaxel and an apoptotic agent; induces apoptosis in JR4-Jurkat leukemia

Baccatin III – 5 mg

Brand:
Cayman
CAS:
27548-93-2
Storage:
-20
UN-No:
Non-Hazardous - /

Baccatin III is a polycyclic diterpene originally isolated from the yew tree (Taxus) that is a precursor of paclitaxel (Item No. 10461).{37435,37436} Baccatin III induces apoptosis in JR4-Jurkat leukemia, HepG2 liver hepatocellular carcinoma, HeLa cervical, OVCAR-3 ovarian carcinoma, and T47D breast cancer cell lines (IC50s = 3.5, 3, 4, 5, and 2 μM, respectively).{37437} It dose-dependently increases the antigen presenting cell (APC) capacity of bone marrow-derived dendritic cells (BM-DCs) sensitized to OVA peptide but does not affect their phagocytic activity.{37438} Baccatin III (0.5 mg/kg per day) decreases tumor growth of 4T1 mammary carcinoma and CT26 colon carcinoma flank implants by 65.6 and 63.9%, respectively, as well as inhibits the accumulation and activity of myeloid-derived suppressor cells (MDSCs) in spleen in immunocompetent mice.{37439}  

 

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Description

A precursor of paclitaxel and an apoptotic agent; induces apoptosis in JR4-Jurkat leukemia, HepG2 liver hepatocellular carcinoma, HeLa cervical, OVCAR-3 ovarian carcinoma, and T47D breast cancer cell lines (IC50s = 3.5, 3, 4, 5, and 2 μM, respectively); increases APC capacity of BM-DCs; decreases tumor growth of 4T1 mammary carcinoma and CT26 colon carcinoma flank implants as well as inhibits the accumulation and activity of MDSCs in spleen in immunocompetent mice

Formal name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one

Synonyms:  NSC 330753

Molecular weight: 586.6

CAS: 27548-93-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death|Apoptosis

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