A DHODH inhibitor; induces differentiation in the acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) with an EC50 value of ~2 µM in both

ML-390 – 5 mg

Brand:
Cayman
CAS:
2029049-79-2
Storage:
-20
UN-No:
Non-Hazardous - /

ML-390 is an inhibitor of dihydroorotate dehydrogenase (DHODH), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis.{39048} In acute myeloid leukemia, leukemic myeloblast development is halted at an immature stage leading to perpetual self-renewal rather than differentiation. ML-390 induces differentiation in the acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) cell lines with an EC50 value of approximately 2 µM.  

 

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Description

A DHODH inhibitor; induces differentiation in the acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) with an EC50 value of ~2 µM in both,

Formal name: N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)-benzamide

Synonyms: 

Molecular weight: 406.4

CAS: 2029049-79-2

Purity: ≥98%

Formulation: A crystralline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cancer Stem Cell Research|Differentiation||Research Area|Cancer|Cell Cycle

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