A selective

ARQ-092 – 5 mg

Brand:
Cayman
CAS:
1313881-70-7
Storage:
-20
UN-No:
Non-Hazardous - /

ARQ-092 is an allosteric, orally bioavailable, pan-Akt inhibitor (IC50s = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively).{33792} It is selective for Akt isoforms over a panel of 303 other kinases.{33792} ARQ-092 binds inactive Akt and prevents membrane localization and full Akt activation.{33792,33790} It also directly inhibits the membrane-associated active form of Akt, preventing phosphorylation of downstream targets.{33792,33790} ARQ-092 inhibits the proliferation of a wide range of cancer cells in vitro, inhibits the mutated Akt form found in Proteus syndrome, and attenuates heterotypic cell-cell interactions in a mouse model of sickle cell disease.{33792,33790,32947,33791}  

 

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Description

A selective, allosteric, orally bioavailable, pan-Akt inhibitor (IC50s = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively)

Formal name: 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl]-2-pyridinamine

Synonyms: 

Molecular weight: 432.5

CAS: 1313881-70-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKB/Akt||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|ECM & Adhesion Molecules

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