A selective inhibitor of mutant EGFR that exhibits a 298-fold increase in potency compared with wild-type EGFR; oral administration at 500 mg/kg regresses tumors with EGFR-active and T790M mutations in a xenograft model

Avitinib – 1 mg

Brand:
Cayman
CAS:
1557267-42-1
Storage:
-20
UN-No:
Non-Hazardous - /

Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). It is selective for EGFR-active and T790M mutations, exhibiting a 298-fold increase in potency compared with wild-type EGFR.{33610} In a xenograft model, oral administration of 500 mg/kg avitinib was shown to result in complete remission of tumors with EGFR-active and T790M mutations.{33610}  

 

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Description

A selective inhibitor of mutant EGFR that exhibits a 298-fold increase in potency compared with wild-type EGFR; oral administration at 500 mg/kg regresses tumors with EGFR-active and T790M mutations in a xenograft model

Formal name: N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide

Synonyms:  AC0010

Molecular weight: 487.5

CAS: 1557267-42-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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