An active metabolite of tazarotene

Tazarotenic Acid – 25 mg

Brand:
Cayman
CAS:
118292-41-4
Storage:
-20
UN-No:
Non-Hazardous - /

Tazarotenic acid is an active metabolite of tazarotene, an acetylenic retinoid prodrug that induces epidermal hyperplasia with an ED50 value of 100 nM.{33614,27013} Tazarotenic acid selectively binds retinoic acid receptors (RAR-β and RAR-γ) in vitro.{33614} It has a relatively short elimination half-life of one to two hours and is metabolized by cytochrome P450 (CYP) isoforms CYP2C8, CYP26A1, and CYP26B1.{33614,33615}  

 

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Description

An active metabolite of tazarotene, an acetylenic retinoid prodrug that induces epidermal hyperplasia with an ED50 value of 100 nM

Formal name: 6-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid

Synonyms:  AGN 190299

Molecular weight: 323.4

CAS: 118292-41-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs

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