An inhibitor of FGFR4 (IC50 = 1.3 nM); selective for FGFR4 over FGFR1 and a panel of 36 kinases (IC50s = >10 µM for all); inhibits proliferation of Hep3B and Huh7 hepatic cancer cells with IC50 values of 1.1 and 2.5 nM

FGFR4-IN-1 – 10 mg

Brand:
Cayman
CAS:
1708971-72-5
Storage:
-20
UN-No:
Non-Hazardous - /

FGFR-IN-1 is an inhibitor of FGF receptor 4 (FGFR4; IC50 = 1.3 nM).{43774} It is selective for FGFR4 over FGFR1 and a panel of 36 kinases (IC50s = >10 µM for all). It inhibits proliferation of Hep3B and Huh7 hepatic cancer cells with IC50 values of 1.1 and 2.5 nM, respectively. FGFR-IN-1 reduces tumor growth by 62.7 and 70.8% in a Huh7 mouse xenograft model when administered at doses of 30 and 100 mg/kg per day, respectively.  

 

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Description

An inhibitor of FGFR4 (IC50 = 1.3 nM); selective for FGFR4 over FGFR1 and a panel of 36 kinases (IC50s = >10 µM for all); inhibits proliferation of Hep3B and Huh7 hepatic cancer cells with IC50 values of 1.1 and 2.5 nM, respectively; reduces tumor growth by 62.7 and 70.8% in a Huh7 mouse xenograft model at 30 and 100 mg/kg per day, respectively

Formal name: N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(3-oxo-4-morpholinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide

Synonyms: 

Molecular weight: 493.5

CAS: 1708971-72-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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