A potent and selective inhibitor of ALK (IC50 50 = 15 nM); reduces H3122 xenograft growth

Ensartinib – 5 mg

Brand:
Cayman
CAS:
1365267-27-1
Storage:
-20
UN-No:
Non-Hazardous - /

Ensartinib is a potent and selective inhibitor of anaplastic lymphoma kinase (ALK; IC50 50 = 15 nM) but has no effect on cell growth driven by other mutant kinases or that of non-cancerous HepG2 cells. Ensartinib, at a dose of 25 mg/kg, reduces H3122 xenograft growth with no effect on body weight in nude mice. It is also brain-permeable to a concentration of 65 nM. Formulations containing ensartinib are being used to treat non-small cell lung cancer in Phase I/II clinical trials.{29756}  

 

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Description

A potent and selective inhibitor of ALK (IC50 50 = 15 nM); reduces H3122 xenograft growth ,

Formal name: 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-3-pyridazinecarboxamide

Synonyms: 

Molecular weight: 547.4

CAS: 1365267-27-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ALK (Activin-like Kinase) Signaling||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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