A potent and selective PARP1 inhibitor; selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1

NMS-P118 – 25 mg

Brand:
Cayman
CAS:
1262417-51-5
Storage:
-20
UN-No:
Non-Hazardous - /

NMS-P118 is an orally bioavailable, potent, and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1), which is an enzyme activated by DNA damage and is critical for the repair of DNA single-strand breaks via the base excision repair pathway.{34675,20553} NMS-P118 is selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390 nM). It is efficacious in MDA-MD-436 human breast and Capan-1 human pancreatic cancer mouse xenograft models.  

 

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Description

A potent and selective PARP1 inhibitor; selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390 nM); efficacious in mouse xenograft models of breast and pancreatic cancer

Formal name: 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide

Synonyms: 

Molecular weight: 395.4

CAS: 1262417-51-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|DNA Damage and Repair|PARP

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