A P-gp inhibitor; inhibits the efflux of [3H]vinblastine by ABCB1 in Caco-2 colon cancer cells (EC50 = 0.05 µM); inhibits the efflux of rhodamine-123 and calcein-AM by BCRP and MRP1 in MDCK cells (EC50s = 73 and 9.3 µM

MC70 – 10 mg

Brand:
Cayman
CAS:
1031367-64-2
Storage:
-20
UN-No:
Non-Hazardous - /

MC70 is a P-glycoprotein (P-gp) inhibitor.{45376} It inhibits the efflux of [3H]vinblastine by ATP binding cassette subfamily B member 1 (ABCB1) in Caco-2 colon cancer cells (EC50 = 0.05 µM). MC70 also inhibits the efflux of rhodamine-123 (Item No. 16672) and calcein-AM (Item No. 14948) by breast cancer resistant protein (BCRP) and multidrug resistance-associated protein 1 (MRP1) in MDCK cells (EC50s = 73 and 9.3 µM, respectively). MC70 (2 or 20 µM) enhances growth inhibition of adriamycin and doxorubicin-resistant (ADR) MCF-7/ADR breast cancer cells when used in combination with doxorubicin (Item No. 15007), but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells.{45377} It increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 µM.  

 

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Description

A P-gp inhibitor; inhibits the efflux of [3H]vinblastine by ABCB1 in Caco-2 colon cancer cells (EC50 = 0.05 µM); inhibits the efflux of rhodamine-123 and calcein-AM by BCRP and MRP1 in MDCK cells (EC50s = 73 and 9.3 µM, respectively); enhances growth inhibition of MCF-7/ADR breast cancer cells at 2 or 20 µM when used in combination with doxorubicin in vitro, but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells; increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 µM

Formal name: 4′-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)methyl]-[1,1′-biphenyl]-4-ol

Synonyms: 

Molecular weight: 375.5

CAS: 1031367-64-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Multidrug Resistance

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