A pharmacologically active flavonol glucuronide; reduced rat immobility time in the forced swim test (0.6 mg/kg); reduced stress-induced hyperthermia in mice (1.2 mg/kg)

Quercetin 3-O-glucuronide – 10 mg

Brand:
Cayman
CAS:
22688-79-5
Storage:
-20
UN-No:
Non-Hazardous - /

Quercetin 3-O-glucuronide is a pharmacologically active flavonol glucuronide isolated from H. perforatum (St. John’s wort) that inhibits the α2c adrenergic receptor (Ki = 4,060 nM in hα2c preparations).{33869,33870, 33974} Quercetin 3-O-glucuronide (0.6 mg/kg) reduced the time rats spent immobile in the forced swim test, suggesting antidepressant-like properties, when given either acutely or chronically.{33867} It also reduced open field stress-induced hyperthermia in mice (at 1.2 mg/kg).{33868}  

 

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Description

A pharmacologically active flavonol glucuronide; reduced rat immobility time in the forced swim test (0.6 mg/kg); reduced stress-induced hyperthermia in mice (1.2 mg/kg)

Formal name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-1-benzopyran-3-ylβ-D-glucopyranosiduronic acid

Synonyms:  Miquelianin|Quercetin 3-O-β-D-glucuronide

Molecular weight: 478.4

CAS: 22688-79-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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