An inhibitor of the HCV viral replication protein NS5A; has broad antiviral activity in vitro against the HCV strain subtypes 1a

Velpatasvir – 250 mg

Brand:
Cayman
CAS:
1377049-84-7
Storage:
-20
UN-No:
Non-Hazardous - /

Velpatasvir is a second generation direct-acting inhibitor of NS5A, a non-structural protein required for replication of the hepatitis C virus (HCV).{33519} It has broad antiviral activity in vitro against the HCV strain subtypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, 6a, and 6e (EC50 = 6-130 pM).{33517} A phase 1 clinical trial concluded that once daily doses of velpatasvir from 5-150 mg were well tolerated and provided significant viral reduction.{33518}  

 

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Description

An inhibitor of the HCV viral replication protein NS5A; has broad antiviral activity in vitro against the HCV strain subtypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, 6a, and 6e (EC50 = 6-130 pM)

Formal name: N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4′,3′:6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-1-phenylethyl]-carbamic acid, methyl ester

Synonyms:  GS-5816

Molecular weight: 883

CAS: 1377049-84-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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