A selective VEGFR2 inhibitor (IC50 = 1 nM); inhibits the proliferation of HUVECs stimulated by FBS and prevents the growth of several established human tumor xenograft models

Apatinib – 10 mg

Brand:
Cayman
CAS:
811803-05-1
Storage:
-20
UN-No:
Non-Hazardous - /

Apatinib is a tyrosine kinase inhibitor that potently suppresses the kinase activity of vascular endothelial growth factor 2 (VEGFR2; IC50 = 1 nM).{33574} It is less effective against c-kit (IC50 = 429 nM), Ret (IC50 = 13 nM), and c-src (IC50 = 53 nM) and does not inhibit EGFR, Her-2, or FGFR1 (IC50s = >10 µM).{33574} Apatinib has been shown to inhibit the proliferation, migration, and tube formation of human umbilical vein endothelial cells stimulated by fetal bovine serum and, either alone, or in combination with chemotherapeutic agents, prevented the growth of several established human tumor xenograft models.{33574}  

 

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Description

A selective VEGFR2 inhibitor (IC50 = 1 nM); inhibits the proliferation of HUVECs stimulated by FBS and prevents the growth of several established human tumor xenograft models

Formal name: N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide

Synonyms:  YN968D1

Molecular weight: 397.5

CAS: 811803-05-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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