An inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM); lowers urate levels in the serum of patients with hyperuricemia

Topiroxostat – 5 mg

Brand:
Cayman
CAS:
577778-58-6
Storage:
-20
UN-No:
Non-Hazardous - /

Topiroxostat is an inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM), an enzyme that converts xanthine to urate.{33356} Formulations containing topiroxostat are effective in vivo, lowering urate levels in the serum of patients with hyperuricemia.{33354} In rats, but not primates, topiroxostat treatment results in the formation of xanthine crystals, resulting in nephritis.{33357,33358} Topiroxostat also inhibits ATP-binding cassette transporter G2 (ABCG2; IC50 = 0.18 µM), a high-capacity urate transporter that functions in both renal and extrarenal urate secretion.{33355}  

 

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Description

An inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM); lowers urate levels in the serum of patients with hyperuricemia

Formal name: 4-[3-(4-pyridinyl)-1H-1,2,4-triazol-5-yl]-2-pyridinecarbonitrile

Synonyms:  FYX-051

Molecular weight: 248.2

CAS: 577778-58-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Xanthine Oxidase

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