A cell-permeable inhibitor of MMPs that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both); less effectively inhibits MMP-1

MMP-9/MMP-13 Inhibitor I – 1 mg

Brand:
Cayman
CAS:
204140-01-2
Storage:
-20
UN-No:
Non-Hazardous - /

MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both).{33201} It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively).{33201} MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.{33202,33203,33204}  

 

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Description

A cell-permeable inhibitor of MMPs that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both); less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively)

Formal name: 4-([1,1′-biphenyl]-4-ylcarbonyl)-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-2-piperazinecarboxamide

Synonyms:  Matrix Metalloproteinase-9/Matrix Metalloproteinase-13 Inhibitor I

Molecular weight: 495.6

CAS: 204140-01-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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