Description
A mitochondrial-targeted neuroprotective agent; binds to and inhibits mPTP opening; prevents arachidonic acid-induced mPTP opening in HeLa cells at 10 µM; promotes survival of motor neurons in vitro in the absence of neurotrophic factors (EC50 = 3.2 µM); promotes survival of motor neurons in vivo in a neonatal rat model of facial nerve axotomy at 100 mg/kg per day; delays onset of motor deficits and extends survival in the SOD1G93A transgenic model of ALS; increases the latency to paw withdrawal in a mechanical hyperalgesia test in rat models of streptozotocin-induced diabetic and vincristine-induced neuropathic pain at 30 and 100 mg/kg
Formal name: cholest-4-en-3-one, oxime
Synonyms: NSC 21311
Molecular weight: 399.7
CAS: 22033-87-0
Purity: ≥95% (mixture of isomers)
Formulation: A crystalline solid
Product Type|Biochemicals||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Pain Research