A prodrug to the long-acting ACE inhibitor moexiprilat; also inhibits PDE4 (IC50 = 38 µM for the PDE4B2 isoform)

Moexipril (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
82586-52-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Moexipril (hydrochloride) is a prodrug to the long-acting angiotensin converting enzyme inhibitor moexiprilat (IC50s = 2.1 nM and 2.7 µM for moexiprilat and moexipril, respectively).{33383} In addition to its antihypertensive activity, moexipril has been identified as a phosphodiesterase 4 inhibitor (IC50 = 38 µM for the PDE4B2 isoform) that increases cAMP in cells.{33382}  

 

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Description

A prodrug to the long-acting ACE inhibitor moexiprilat; also inhibits PDE4 (IC50 = 38 µM for the PDE4B2 isoform), increasing cAMP in cells

Formal name: 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3S-isoquinolinecarboxylic acid, monohydrochloride

Synonyms:  CI-925|RS 10085-197|SPM 925

Molecular weight: 535

CAS: 82586-52-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Angiotensin-converting Enzyme||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension

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