A chromogenic substrate that can be cleaved by DPP IV; enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm

Gly-Pro-pNA (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
103213-34-9
Storage:
-20
UN-No:
Non-Hazardous - /

Gly-Pro-pNA is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV).{33566} Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm. DPP IV inactivates the two peptides responsible for a majority of nutrient-stimulated insulin secretion: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1). This substrate can be used to screen for DPP IV inhibitors, which have emerged as a new class of experimental antidiabetic agents.{29892}  

 

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Description

A chromogenic substrate that can be cleaved by DPP IV; enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm

Formal name: glycyl-N-(4-nitrophenyl)-L-prolinamide, monohydrochloride

Synonyms:  Gly-Pro p-nitroanilide|GP-pNA

Molecular weight: 328.8

CAS: 103213-34-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection|Dyes, Stains, & Indicators||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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