An orally-bioavailable antagonist of 5-HT3 (Ki = 5.3 nM) that prevents nausea and emesis; an antagonist of α9 nAChR (IC50 = 166 nM) and a partial agonist of α7 nAChR (Ki = 6.9 nM)

Tropisetron (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
105826-92-4
Storage:
-20
UN-No:
Non-Hazardous - /

Tropisetron is an orally-bioavailable antagonist of the serotonin (5-HT) receptor 5-HT3 (Ki = 5.3 nM).{33369,33371} Antagonists of 5-HT3, including tropisetron, have been shown to prevent nausea and emesis in patients undergoing chemotherapy in clinical trials.{33373,33374} Tropisetron is also an antagonist of the α9 nicotinic acetylcholine receptor (nAChR; IC50 = 166 nM) and a partial agonist of α7 nAChR (Ki = 6.9 nM).{33372,33370}  

 

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Description

An orally-bioavailable antagonist of 5-HT3 (Ki = 5.3 nM) that prevents nausea and emesis; an antagonist of α9 nAChR (IC50 = 166 nM) and a partial agonist of α7 nAChR (Ki = 6.9 nM)

Formal name: 1H-indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, monohydrochloride

Synonyms:  ICS 205-930|SDZ-ICS 930

Molecular weight: 320.8

CAS: 105826-92-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience

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