An inhibitor of microtubule polymerization (IC50 = 0.4-1.7 µM); blocks taxol-induced assembly of tubulin (IC50 = 6 µM) and blocks colchicine binding to tubulin

TN-16 – 50 mg

Brand:
Cayman
CAS:
33016-12-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 µM).{33289} It blocks taxol-induced assembly of tubulin (IC50 = 6 µM) and blocks colchicine (Item No. 9000760) binding to tubulin.{33289} Like colchicine, TN-16 inhibits alkylation of tubulin.{33292} TN-16 induces metaphase arrest in renal cell carcinoma cells.{33291} TN-16 can be used in combination with other inhibitors to enhance the efficiency of human artificial chromosome transfer to recipient cells.{33290}  

 

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Description

An inhibitor of microtubule polymerization (IC50 = 0.4-1.7 µM); blocks taxol-induced assembly of tubulin (IC50 = 6 µM) and blocks colchicine binding to tubulin

Formal name: 3-[1-(phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione

Synonyms:  NSC 239274

Molecular weight: 306.4

CAS: 33016-12-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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