Bestatin – 100 mg

Brand:
Cayman
CAS:
58970-76-6
Storage:
-20
UN-No:
Non-Hazardous - /

Bestatin is an aminopeptidase inhibitor originally isolated from S. olivoreticuli.{33261} It inhibits aminopeptidase B (IC50 = 0.05 µg/ml), aminopeptidase N (IC50 = 16.9 µM), leucine aminopeptidase (IC50 = 0.01 µg/ml), and the aminopeptidase activity of leukotriene A4 (LTA4) hydrolase (Kapp = 172 nM).{33261,48771,91} It is selective for these aminopeptidases over aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, and thermolysin.{33261} Bestatin inhibits the production of LTB4 (Item No. 20110) in erythrocytes when used at a concentration of 70 µM.{91} It increases the expression of Akt, inhibits proliferation, migration, and invasion, and induces autophagy and apoptosis in 5637 bladder cancer cells.{48772} Bestatin (5 and 15 mg/kg) decreases serum levels of LTB4 and reduces tumor growth in a patient-derived xenograft (PDX) mouse model of colorectal cancer.{48773}  

 

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Description

,An aminopeptidase inhibitor; inhibits aminopeptidase B (IC50 = 0.05 µg/ml), aminopeptidase N (IC50 = 16.9 µM), leucine aminopeptidase (IC50 = 0.01 µg/ml), and the aminopeptidase activity of leukotriene A4 (LTA4) hydrolase (Kapp = 172 nM); selective for these aminopeptidases over aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, and thermolysin; inhibits LTB4 production in erythrocytes at 70 µM; increases the expression of Akt, inhibits proliferation, migration, and invasion, and induces autophagy and apoptosis in 5637 bladder cancer cells; decreases serum levels of LTB4 and reduces tumor growth in a PDX mouse model of colorectal cancer at 5 and 15 mg/kg

Formal name: N-[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine

Synonyms:  NK 421|NSC 265489

Molecular weight: 308.4

CAS: 58970-76-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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