Description
A potent inhibitor of LIMK1, LIMK2, ROCK-1, and ROCK-2 kinases (IC50s = 32, 4.3, 69, and 32 nM, respectively); selective, showing no cross reactivity in a panel of binding assays including 78 receptors, at a concentration of 10 μM; topical administration (3 μl of 1 mg/ml solution) to the eye reduces intraocular pressure in a dexamethasone-induced mouse model of glaucoma,
Formal name: N,N-dimethyl-carbamic acid, 3-[[[4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]carbonyl]amino]phenyl ester, monohydrochloride
Synonyms:
Molecular weight: 488
CAS: 2319882-48-7
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Kinase Inhibitors|ROCK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Neuroscience|Ophthalmology
