An inhibitor of mTOR (IC50 = 0.45 nM); selective for mTOR over PI3Kα (IC50 = 661 nM); inhibits cell growth in LNCaP cells (IC50 = 42 nM)

WYE-23 – 1 mg

Brand:
Cayman
CAS:
1062169-46-3
Storage:
-20
UN-No:
Non-Hazardous - /

WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR; IC50 = 0.45 nM).{20314,48484} It is selective for mTOR over PI3Kα (IC50 = 661 nM).{20314} WYE-23 inhibits cell growth in LNCaP cells (IC50 = 42 nM).  

 

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Description

An inhibitor of mTOR (IC50 = 0.45 nM); selective for mTOR over PI3Kα (IC50 = 661 nM); inhibits cell growth in LNCaP cells (IC50 = 42 nM)

Formal name: 4-[6-[4-[[(cyclopropylamino)carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid, methyl ester

Synonyms:  mTOR Inhibitor WYE-23

Molecular weight: 520.6

CAS: 1062169-46-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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