A serine protease inhibitor; inhibits enzyme activity of 24 serine proteases including human leukocyte elastase

3,4-Dichloroisocoumarin – 5 mg

Brand:
Cayman
CAS:
51050-59-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

3,4-Dichloroisocoumarin (3,4-DCI) is a serine protease inhibitor.{38255} It completely inhibits enzyme activity of 24 serine proteases including human leukocyte elastase, thrombin, plasmin, Factor Xa, and Factor XIIa in vitro. 3,4-DCI stimulates caseinolytic activity of bovine pituitary multicatalytic proteinase complex (MPC) by inducing a conformational change in the MPC that exposes the caseinolytic active site.{38256} It has been used to functionally characterize the catalytic activities of multiple proteases including rat liver MPC and extracellular lipase.{38257,38258}  

 

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Description

A serine protease inhibitor; inhibits enzyme activity of 24 serine proteases including human leukocyte elastase, thrombin, plasmin, Factor Xa, and Factor XIIa in vitro; stimulates caseinolytic activity of bovine pituitary MPC by inducing a conformational change in the MPC that exposes the caseinolytic active site; has been used to functionally characterize the catalytic activities of multiple proteases including rat liver MPC and extracellular lipase,

Formal name: 3,4-dichloro-1H-2-benzopyran-1-one

Synonyms:  3,4-DCI

Molecular weight: 215

CAS: 51050-59-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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