An IP6K (IC50 = 0.55 µM; Ki = 0.24 µM) and IP3K (IC50 = 10.2 µM; Ki = 4.3 µM) inhibitor; reduces IP7 and IP8 levels; inhibits insulin release in MIN6 cells; increases intracellular calcium levels in a concentration-dependent manner (5-20 µM) in HL-60 cells; increases intracellular calcium and induces degranulation of mast cells

TNP – 5 mg

Brand:
Cayman
CAS:
519178-28-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

TNP is a cell-permeable inhibitor of inositol-1,4,5-trisphosphate 6-kinase 1 (IP6K1; IC50 = 0.55 µM; Ki = 0.24 µM) and IP3K (IC50 = 10.2 µM; Ki = 4.3 µM) that binds to the ATP-binding sites of both enzymes. {38146,38145} TNP reduces IP7 and IP8 levels (IC50s = ~3 and 1 µM, respectively) and inhibits insulin release in MIN6 cells.{38146} It increases intracellular calcium levels in a concentration-dependent manner in HL-60 cells, potentially due to a 2- to 3-fold accumulation of IP3, and induces degranulation in mast cells.{38147}  

 

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Description

An IP6K (IC50 = 0.55 µM; Ki = 0.24 µM) and IP3K (IC50 = 10.2 µM; Ki = 4.3 µM) inhibitor; reduces IP7 and IP8 levels; inhibits insulin release in MIN6 cells; increases intracellular calcium levels in a concentration-dependent manner (5-20 µM) in HL-60 cells; increases intracellular calcium and induces degranulation of mast cells,

Formal name: N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-purine-2,6-diamine

Synonyms:  IP3K Inhibitor|IP6K Inhibitor

Molecular weight: 443.4

CAS: 519178-28-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Cell Biology|Inositol Phosphates||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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