A structural analog of glucagon receptor antagonist I; inhibits glucagon binding GCGR by only 20% in CHO cells expressing human GCGR at 50 µM; has no effect on glucagon-induced glycogenolysis in primary human hepatocytes at 10 or 30 µM

Glucagon Receptor Antagonist Inactive Control – 5 mg

Brand:
Cayman
CAS:
362482-00-6
Storage:
-20
UN-No:
Non-Hazardous - /

Glucagon receptor antagonist inactive control is an analog of glucagon receptor antagonist I (Item No. 21223).{33305} It inhibits glucagon binding to the glucagon receptor (GCGR) by only 20% in CHO cells expressing human GCGR when used at a concentration of 10 µM. Glucagon receptor antagonist inactive control has no effect on glucagon-induced glycogenolysis in primary human hepatocytes when used at concentrations of 10 or 30 µM.  

 

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Description

A structural analog of glucagon receptor antagonist I; inhibits glucagon binding GCGR by only 20% in CHO cells expressing human GCGR at 50 µM; has no effect on glucagon-induced glycogenolysis in primary human hepatocytes at 10 or 30 µM

Formal name: 4-bromo-N-[3-cyano-6-(1,1-dimethylpropyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-benzamide

Synonyms:  GCGR Inactive Control

Molecular weight: 431.4

CAS: 362482-00-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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