A guanosine derivative and an agonist of TLR7; selective for TLR7 over other human TLRs in a cell-based reporter assay at 1 mM; induces proliferation

Loxoribine – 10 mg

Brand:
Cayman
CAS:
121288-39-9
Storage:
-20
UN-No:
Non-Hazardous - /

Loxoribine is a guanosine derivative and an agonist of toll-like receptor 7 (TLR7).{42514,42515} It is selective for TLR7 over other human TLRs in a cell-based reporter assay at 1 mM.{42515}. Loxoribine induces proliferation, increases the antibody response to sheep red blood cells, and activates natural killer cell activity against Yac-1 lymphoma cells in murine splenocyte cultures (EC50s = 10-50, 3-20, and 13-22 μM, respectively).{42514} Loxoribine (250 μM) increases production of IL-12, IL-23, IL-27, and IL-10 by human monocyte-derived dendritic cells (MoDCs).{42516} Loxoribine-treated MoDCs induce higher levels of IL-17 and IFN-γ secretion by co-cultured allogeneic CD4+ T cells compared to control MoDCs. Loxoribine (120 mg/kg) reduces the number of pulmonary metastases in the B16 mouse model of melanoma, an effect enhanced by co-administration of IL-2, and exhibits adjuvant activity in mice immunized with a B16 tumor vaccine.{42517}  

 

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Description

A guanosine derivative and an agonist of TLR7; selective for TLR7 over other human TLRs in a cell-based reporter assay at 1 mM; induces proliferation, increases the antibody response to sheep red blood cells, and activates natural killer cell activity against Yac-1 lymphoma cells in murine splenocyte cultures (EC50s = 10-50, 3-20, and 13-22 μM, respectively); increases production of IL-12, IL-23, IL-27, and IL-10 by human MoDCs at 250 μM; loxoribine-treated MoDCs induce higher levels of IL-17 and IFN-γ secretion by co-cultured allogeneic CD4+ T cells compared to control MoDCs; reduces the number of pulmonary metastases in the B16 mouse model of melanoma at 120 mg/kg, an effect enhanced by co-administration of IL-2; exhibits adjuvant activity in mice immunized with a B16 tumor vaccine

Formal name: 7,8-dihydro-8-oxo-7-(2-propen-1-yl)-guanosine

Synonyms:  7-Allyl-8-Oxoguanosine|RWJ 21757

Molecular weight: 339.3

CAS: 121288-39-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition

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