A natural polyisoprenylated benzophenone that has immunosuppressant actions in mouse models of inflammatory or autoimmune disease; inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 µg/ml

Isogarcinol – 1 mg

Brand:
Cayman
CAS:
71117-97-0
Storage:
-20
UN-No:
Non-Hazardous - /

Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 µM) and suppressing the proliferation of T cells.{33025} Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis.{33025,33026,33028} Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 µg/ml, respectively) through cell cycle arrest and apoptosis.{33027}  

 

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Description

A natural polyisoprenylated benzophenone that has immunosuppressant actions in mouse models of inflammatory or autoimmune disease; inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 µg/ml, respectively) through cell cycle arrest and apoptosis

Formal name: (3S,4aS,6R,8R)-10-(3,4-dihydroxybenzoyl)-3,4,5,6,7,8-hexahydro-2,2,7,7-tetramethyl-3,6,8-tris(3-methyl-2-buten-1-yl)-9H-4a,8-methano-2H-cycloocta[b]pyran-9,11-dione

Synonyms:  Cambogin

Molecular weight: 602.8

CAS: 71117-97-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Lipid Biochemistry|Prenol Lipids

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