A 13-methyl-substituted derivative of berberine; has antibacterial

13-Methylberberine (chloride) – 5 mg

Brand:
Cayman
CAS:
54260-72-9
Storage:
-20
UN-No:
Non-Hazardous - /

13-Methylberberine (13-MB) (chloride) is a 13-methyl-substituted derivative of berberine (Item No. 10006427). Berberine is a widely distributed berberidaceaen alkaloid found in plant tissues that has antibacterial, anti-inflammatory, antitumor, anti-obesity, and hypercholesterolemic activity.{32930,12390} 13-MB has improved antibacterial activity against S. aureus (MIC = 125 µg/ml) and improved antitumor activity with a mean GI50 value of 11.7 µM, as compared to berberine.{37022,37023,37024} 13-MB also induces down-regulation of adipocyte differentiation transcription factors, reduces de novo lipid synthesis, and accumulates in murine 3T3-L1 adipocytes at higher levels than berberine, suggesting improved anti-obesity activity.{32930}  

 

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Description

A 13-methyl-substituted derivative of berberine; has antibacterial, anti-inflammatory, anti-obesity, and hypercholesterolemic activity; has improved antibacterial activity against S. aureus (MIC = 125 µg/ml) and improved antitumor activity compared to berberine; induces down-regulation of adipocyte differentiation transcription factors; reduces de novo lipid synthesis

Formal name: 5,6-dihydro-9,10-dimethoxy-13-methyl-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, monochloride

Synonyms:  13-MB

Molecular weight: 385.8

CAS: 54260-72-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer||Research Area|Endocrinology & Metabolism||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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