An LXR modulator that acts as a partial agonist at LXRα and a full agonist at LXRβ (IC50s = 179 and 24 nM

LXR-623 – 1 mg

Brand:
Cayman
CAS:
875787-07-8
Storage:
-20
UN-No:
De Minimis - / 6.1

LXR-623 is a liver X receptor (LXR) modulator that acts as a partial agonist at LXRα and a full agonist at LXRβ (IC50s = 179 and 24 nM, respectively).{33455,32907} It is orally bioavailable and readily passes the blood-brain barrier.{33455,32907,32909} LXR-623 is anti-atherogenic in animal models of atherosclerosis, showing synergistic effects when combined with simvastatin (Item Nos. 10010344 | 10010345).{33455,33456,32907}  

 

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Description

An LXR modulator that acts as a partial agonist at LXRα and a full agonist at LXRβ (IC50s = 179 and 24 nM, respectively); orally bioavailable and readily passes the BBB; anti-atherogenic in animal models of atherosclerosis

Formal name: 2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole

Synonyms:  WAY-252623

Molecular weight: 422.8

CAS: 875787-07-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis

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